"Walter and Eliza Hall
Institute researchers have defined for the first time how the size of
the immune response is controlled, using mathematical models to predict
how powerfully immune cells respond to infection and disease." according to Phys.Org.
|Dr Andrey Kan, Ms Julia
Marchingo, Dr Susanne Heinzel and Professor Phil Hodgkin have combined
mathematics and laboratory studies to define how the size of the immune
response is controlled. |
Credit: Walter and Eliza Hall Institute, Australia
The research team used mathematics and computer modeling to understand how complex signaling impacts the size of the response by key infection-fighting immune cells called T cells. The team included Ms Julia Marchingo, Dr Andrey Kan, Dr Susanne Heinzel and Professor Phil Hodgkin from the Walter and Eliza Hall Institute, and Professor Ken Duffy from the National University of Ireland, Maynooth.
T cells are important for launching specific immune responses against invading microbes, as well as eliminating some cancer cells. Errors in the control of T cells can lead to harmful 'autoimmune' responses that attack the body's own tissues, the underlying cause of diseases including type 1 diabetes and rheumatoid arthritis.
The team combined laboratory data with mathematical models to clarify how different external signals impact on T cell proliferation, Ms Marchingo said. "The more times T cells divide, the more powerfully they can fight their target," she said. "For example, if T cells are responding to a vaccine, more division can produce a better protective immune response.
"The outcome of our research is that, for the first time, we are able to predict the size of an immune response, such as the response to flu virus, based on the sum of the signals received by the flu-responsive T cells."
"Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion," by J.M. Marchingo et al. Science, 2014.